{"id":8313,"date":"2026-05-08T22:24:46","date_gmt":"2026-05-08T22:24:46","guid":{"rendered":"https:\/\/trusthillpharma.de\/?post_type=product&#038;p=8313"},"modified":"2026-05-29T21:53:22","modified_gmt":"2026-05-29T21:53:22","slug":"oxycontin-80mg","status":"publish","type":"product","link":"https:\/\/trusthillpharma.de\/nl\/product\/oxycontin-80mg\/","title":{"rendered":"Oxycontin 80 mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Oxycontin<\/a> 80mg<\/h1>\n<div>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\" data-message-id=\"b3-qqov2ScRehgun9NPjO\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div>\n<div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharma.de\/\">OxyContin<\/a> 80mg is a brand-name extended-release formulation of <strong>oxycodone hydrochloride<\/strong>, a potent opioid analgesic. The 80mg strength is one of the higher doses, typically prescribed for severe, chronic pain management (e.g., cancer pain or post-surgical recovery) in opioid-tolerant patients. It&#8217;s designed for\u00a0<strong>12-hour dosing<\/strong>\u00a0to provide steady pain relief, not for immediate-release use like breakthrough pain.<\/p>\n<h4>Key Facts and Evidence<\/h4>\n<ul>\n<li><strong>Pharmacology<\/strong>: Oxycodone is a semi-synthetic opioid agonist binding to mu-opioid receptors in the brain and spinal cord, altering pain perception. The extended-release coating (abuse-deterrent formulation since 2010) uses a polymer matrix to slow dissolution, reducing crushing\/snorting potential. Peak plasma levels occur ~3 hours post-dose; half-life is 4.5 hours (source: FDA prescribing info, Purdue Pharma).<\/li>\n<li><strong>Dosing Guidelines<\/strong>\u00a0(from FDA-approved label):<\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Patient Type<\/th>\n<th>Starting Dose<\/th>\n<th>Titration<\/th>\n<th>Max Daily<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Opioid-naive<\/td>\n<td>Not recommended (use lower strengths like 10-20mg)<\/td>\n<td>Increase by 25-50% every 1-2 days<\/td>\n<td>80mg (split BID)<\/td>\n<\/tr>\n<tr>\n<td>Opioid-tolerant<\/td>\n<td>40-80mg every 12 hours<\/td>\n<td>Adjust based on pain\/response<\/td>\n<td>No strict max; monitor closely<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<ul>\n<li><strong>80mg specifics<\/strong>: Green-colored, round tablet (OP 80 imprint). Equivalent to ~120mg oral morphine daily when dosed BID. Not for children under 11 or &lt;50kg.<\/li>\n<li><strong>Clinical Efficacy<\/strong>: Studies (e.g., NEJM 2003 trial) show it reduces chronic pain scores by 30-50% in tolerant patients vs. placebo, but tolerance develops quickly (weeks).<\/li>\n<\/ul>\n<h4>Risks and Side Effects<\/h4>\n<p class=\"mb-2 last:mb-0\">High-strength doses like 80mg carry\u00a0<strong>significant risks<\/strong>, substantiated by CDC data and FDA black-box warnings:<\/p>\n<ul>\n<li><strong>Overdose<\/strong>: Respiratory depression is primary cause of death. Lethal dose ~200mg in naive users (equianalgesic calculators like CDC&#8217;s). Naloxone reverses it.<\/li>\n<li><strong>Common Side Effects<\/strong>\u00a0(&gt;10% incidence): Constipation (40-60%), nausea (23%), drowsiness (23%), itching (15%).<\/li>\n<li><strong>Serious Risks<\/strong>:<\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Risk<\/th>\n<th>Incidence\/Evidence<\/th>\n<th>Mitigation<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Addiction\/Dependence<\/td>\n<td>8-12% in chronic users (JAMA 2014 meta-analysis)<\/td>\n<td>Screen with Opioid Risk Tool; taper slowly<\/td>\n<\/tr>\n<tr>\n<td>Respiratory Failure<\/td>\n<td>1-2% hospitalized (per 10,000 scripts, FDA)<\/td>\n<td>Monitor SpO2; avoid alcohol\/Benzos<\/td>\n<\/tr>\n<tr>\n<td>Hyperalgesia<\/td>\n<td>Paradoxical pain increase (animal\/human studies, Pain 2017)<\/td>\n<td>Rotate opioids if suspected<\/td>\n<\/tr>\n<tr>\n<td>Neonatal Abstinence (pregnancy)<\/td>\n<td>Category C; avoid if possible<\/td>\n<td>Use lowest effective dose<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<ul>\n<li><strong>Abuse Potential<\/strong>: Pre-2010 versions were crushed for rapid high (e.g., &#8220;oxy 80s&#8221; street value $40-80\/pill, DEA reports). Reformulated version gels when crushed, but IV abuse still occurs.<\/li>\n<\/ul>\n<h4>Regulatory and Withdrawal Notes<\/h4>\n<ul>\n<li><strong>Controlled Substance<\/strong>: Schedule II (high abuse potential, DEA). Requires prescription; no refills without MD approval.<\/li>\n<li><strong>Withdrawal<\/strong>: Abrupt stop causes flu-like symptoms (anxiety, sweats, diarrhea) peaking 72 hours. Taper 10-25% weekly (ASAM guidelines).<\/li>\n<li><strong>Interactions<\/strong>: Potentiated by CYP3A4 inhibitors (e.g., ketoconazole); avoid with MAOIs.<\/li>\n<\/ul>\n<h4>Recent Context<\/h4>\n<p class=\"mb-2 last:mb-0\">Post-2010 reformulation reduced abuse rates by 75% (JAMA 2017), but contributed to the opioid crisis (e.g., Purdue&#8217;s\u00a0$8B settlement, 2020). Alternatives: fentanyl patches, buprenorphine for maintenance.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Disclaimer<\/strong>: This is factual info from FDA, CDC, and peer-reviewed sources (e.g., PubMed). Not medical advice\u2014consult a doctor for personal\u00a0 Misuse can be fatal. If seeking treatment, resources like SAMHSA helpline (1-800-662-HELP) available.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\"><\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div> \n","protected":false},"excerpt":{"rendered":"<p>Oxycontin 80mg OxyContin 80mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 80mg strength is one of the higher doses, typically prescribed for severe, chronic pain management (e.g., cancer pain or post-surgical recovery) in opioid-tolerant patients. It&#8217;s designed for\u00a012-hour dosing\u00a0to provide steady pain relief, not for immediate-release use like breakthrough &hellip; <a href=\"https:\/\/trusthillpharma.de\/nl\/product\/oxycontin-80mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Oxycontin 80 mg<\/span><\/a><\/p>","protected":false},"featured_media":8319,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[263],"class_list":["post-8313","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-oxycontin-80mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Oxycontin 80mg - 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