{"id":8217,"date":"2026-05-08T19:36:33","date_gmt":"2026-05-08T19:36:33","guid":{"rendered":"https:\/\/trusthillpharma.de\/?post_type=product&#038;p=8217"},"modified":"2026-05-09T16:22:27","modified_gmt":"2026-05-09T16:22:27","slug":"codeine-fosfaat-2","status":"publish","type":"product","link":"https:\/\/trusthillpharma.de\/nl\/product\/codeine-fosfaat-2\/","title":{"rendered":"Code\u00efnefosfaat"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Code\u00efnefosfaat<\/a><\/h1>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharma.de\/nl\/\">Codeine phosphate<\/a> is de fosfaatzoutvorm van code\u00efne, een van nature voorkomende opio\u00efde alkalo\u00efde afkomstig van de opiumpapaver (<em>Papaver somniferum<\/em>Het is een prodrug die in de lever wordt gemetaboliseerd (voornamelijk door het enzym CYP2D6) tot morfine, wat de belangrijkste pijnstillende werking veroorzaakt. Chemisch gezien is het C\u2081\u2088H\u2082\u2081NO\u2083\u00b7H\u2083PO\u2084, met een moleculair gewicht van 406,37 g\/mol.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Medische Toepassingen<\/strong><\/p>\n<ul>\n<li><strong>Pain relief<\/strong>: Milde tot matige pijn (bijv. na een operatie of tandheelkundige ingreep). Vaak in combinatie met paracetamol (bijv. Tylenol nr. 3) of ibuprofen.<\/li>\n<li><strong>Cough suppression<\/strong>Hoestonderdrukkend middel in siropen (bijvoorbeeld voor droge hoest).<\/li>\n<li><strong>Antidiarrheamiddel<\/strong>: In lage doses (bijvoorbeeld als onderdeel van Lomotil met difenoxylaat).<br \/>\nDe gebruikelijke dosering varieert van 15 tot 60 mg elke 4 tot 6 uur voor volwassenen (maximaal 360 mg per dag), maar personen met een zeer snelle CYP2D6-metabolisatie kunnen toxiciteit ondervinden bij standaarddoseringen.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Farmacologie<\/strong><\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Property<\/th>\n<th>Details<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Klas<\/td>\n<td>Opioid agonist (\u03bc-receptor partial agonist)<\/td>\n<\/tr>\n<tr>\n<td>Begin<\/td>\n<td>30-60 min (oraal); piek na 1-2 uur<\/td>\n<\/tr>\n<tr>\n<td>Duur<\/td>\n<td>4\u20136 hours<\/td>\n<\/tr>\n<tr>\n<td>Halveringstijd<\/td>\n<td>2,5\u20134 uur (code\u00efne); 2\u20134 uur (morfinemetaboliet)<\/td>\n<\/tr>\n<tr>\n<td>Biobeschikbaarheid<\/td>\n<td>~50% oral (first-pass metabolism)<\/td>\n<\/tr>\n<tr>\n<td>Uitscheiding<\/td>\n<td>Urine (10% onveranderd; de rest als metabolieten)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>Bijwerkingen en risico's<\/strong><\/p>\n<ul>\n<li><strong>Common<\/strong>: Slaperigheid, constipatie, misselijkheid, duizeligheid, jeuk.<\/li>\n<li><strong>Ernstig<\/strong>Ademhalingsdepressie (dosisafhankelijk; risico het hoogst bij &gt;200 mg\/dag), verslaving\/afhankelijkheid, overdosis (vernauwde pupillen, coma).<\/li>\n<li><strong>Contra-indicaties<\/strong>: Respiratory depression, acute asthma, paralytic ileus, children &lt;12 (FDA black box for cough\/cold due to apnea risk), breastfeeding (morphine in milk).<\/li>\n<li><strong>Interacties<\/strong>CYP2D6-remmers (bijv. fluoxetine) verminderen de werkzaamheid; kalmeringsmiddelen\/alcohol versterken de depressie.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Juridische Status<\/strong><br \/>\nGereguleerde stof van categorie II in de VS (hoog risico op misbruik); wereldwijd alleen op recept verkrijgbaar. Overdosis wordt behandeld met naloxon.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Evidence Base<\/strong><\/p>\n<ul>\n<li>WHO-lijst van essenti\u00eble geneesmiddelen (pijnstillers).<\/li>\n<li>Studies (bijvoorbeeld Cochrane-reviews) tonen een bescheiden effectiviteit bij pijn\/hoest in vergelijking met placebo, en een effectiviteit die lager is dan die van sterkere opio\u00efden zoals morfine.<\/li>\n<li>Genetische testen worden aanbevolen voor mensen met een trage\/zeer snelle stofwisseling (bijv. ~10% van de blanken met een trage stofwisseling; 1-2% met een zeer snelle stofwisseling).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Fun Fact<\/strong>Code\u00efne werd voor het eerst ge\u00efsoleerd in 1832 door Pierre Jean Robiquet. Recreatief gebruik omvat vaak extractie uit vrij verkrijgbare combinatiepillen (bijvoorbeeld \"lean\" met promethazine), maar de zuiverheid varieert sterk.<\/p>\n<h3>Waarschuwingen:<\/h3>\n<ul>\n<li><strong>Illegale bronnen<\/strong>Op het dark web, bij straatdealers of via ongereguleerde buitenlandse websites (bijvoorbeeld uit India\/Mexico) bestaat het risico op namaakproducten, fentanylverontreiniging, arrestatie of zelfs de dood. In de VS gelden straffen tot 20 jaar gevangenisstraf of boetes voor drugshandel.<\/li>\n<li><strong>Wereldwijde trends<\/strong>: Interpol\/FDA seize millions in illicit shipments yearly; purity often &lt;50%.<\/li>\n<li><strong>Veiligere alternatieven<\/strong>: Bij pijn: ibuprofen\/paracetamol; bij hoest: dextromethorfan (vrij verkrijgbaar).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Dit is geen medisch\/juridisch advies. Raadpleeg de lokale wetgeving (bijv. DEA.gov, EMA.europa.eu).<\/strong>\u00a0Als je het om gezondheidsredenen nodig hebt, overleg dan met een arts.<\/p>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Codeine Phosphate Codeine phosphate is the phosphate salt form of codeine, a naturally occurring opioid alkaloid derived from the opium poppy (Papaver somniferum). It&#8217;s a prodrug metabolized in the liver (primarily by CYP2D6 enzyme) into morphine, which provides its main analgesic effects. Chemically, it&#8217;s C\u2081\u2088H\u2082\u2081NO\u2083\u00b7H\u2083PO\u2084, with a molecular weight of 406.37 g\/mol. Medical Uses Pain &hellip; <a href=\"https:\/\/trusthillpharma.de\/nl\/product\/codeine-fosfaat-2\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Code\u00efnefosfaat<\/span><\/a><\/p>","protected":false},"featured_media":8231,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[15],"product_tag":[245],"class_list":["post-8217","product","type-product","status-publish","has-post-thumbnail","product_cat-uncategorized","product_tag-codeine-phosphate","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Codeine Phosphate - Trusthill Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trusthillpharma.de\/nl\/product\/codeine-fosfaat-2\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Codeine Phosphate\" \/>\n<meta property=\"og:description\" content=\"Codeine Phosphate Codeine phosphate is the phosphate salt form of codeine, a naturally occurring opioid alkaloid derived from the opium poppy (Papaver somniferum). It&#8217;s a prodrug metabolized in the liver (primarily by CYP2D6 enzyme) into morphine, which provides its main analgesic effects. Chemically, it&#8217;s C\u2081\u2088H\u2082\u2081NO\u2083\u00b7H\u2083PO\u2084, with a molecular weight of 406.37 g\/mol. 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