{"id":7736,"date":"2026-04-09T10:15:59","date_gmt":"2026-04-09T10:15:59","guid":{"rendered":"https:\/\/trusthillpharma.de\/?post_type=product&#038;p=7736"},"modified":"2026-04-14T16:02:12","modified_gmt":"2026-04-14T16:02:12","slug":"co-codamol-15-500mg","status":"publish","type":"product","link":"https:\/\/trusthillpharma.de\/it\/product\/co-codamol-15-500mg\/","title":{"rendered":"Co-Codamol 15\/500mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Co-Codamol 15\/500mg<\/a><\/h1>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>What it is:<\/strong><br \/>\n<a href=\"https:\/\/trusthillpharma.de\/it\/\">Co-Codamol<\/a> 15\/500mg \u00e8 un antidolorifico combinato contenente:<\/p>\n<ul>\n<li><strong>fosfato di codeina<\/strong>: 15 mg (un analgesico oppioide che agisce legandosi ai recettori oppioidi nel cervello per ridurre la percezione del dolore).<\/li>\n<li><strong>Paracetamolo (acetaminofene)<\/strong>: 500 mg (un analgesico e antipiretico non oppioide che inibisce la sintesi delle prostaglandine nel sistema nervoso centrale).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\">Si tratta di una formulazione a basso dosaggio (Co-Codamol 15\/500 mg) rispetto a dosaggi pi\u00f9 elevati come 30\/500 o 8\/500. \u00c8 disponibile senza ricetta in alcuni paesi (ad esempio, nel Regno Unito) in confezioni limitate, ma le versioni pi\u00f9 concentrate richiedono la prescrizione medica.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Usi comuni:<\/strong><\/p>\n<ul>\n<li>Sollievo dal dolore lieve a moderato (ad esempio, mal di testa, mal di denti, dolori muscolari, dolori mestruali, indolenzimento post-traumatico).<\/li>\n<li>Solo per uso a breve termine (in genere massimo 3 giorni per i prodotti contenenti codeina, per evitare la dipendenza).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Prove e efficacia:<\/strong><\/p>\n<ul>\n<li>Supportato dalle linee guida del NHS e dagli studi in\u00a0<em>The Lancet<\/em>\u00a0(ad esempio, le combinazioni di codeina e paracetamolo forniscono un'analgesia superiore rispetto al solo paracetamolo per il dolore acuto, con un NNT di circa 4 per un sollievo dal dolore del 50% \u2013 McQuay et al., meta-analisi degli anni '90).<\/li>\n<li>Il co-codamol 15\/500 mg viene metabolizzato in morfina tramite l'enzima CYP2D6; circa il 10% delle persone ha un metabolismo lento e ne trae meno beneficio (avvertenze della FDA su questa variabilit\u00e0).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Dosaggio (adulti):<\/strong><\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Gruppo Di Et\u00e0<\/th>\n<th>Dose massima giornaliera<\/th>\n<th>Note<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Adulti (dai 16 anni in su)<\/td>\n<td>8 compresse (120 mg di codeina \/ 4 g di paracetamolo)<\/td>\n<td>1-2 compresse ogni 4-6 ore; non superare la dose consigliata.<\/td>\n<\/tr>\n<tr>\n<td>Bambini (12-15 anni)<\/td>\n<td>1 compressa ogni 6 ore (massimo 4 al giorno)<\/td>\n<td>Vietato ai minori di 12 anni.<\/td>\n<\/tr>\n<tr>\n<td>Anziani\/Problemi al fegato<\/td>\n<td>Ridurre la dose<\/td>\n<td>Consultare un medico.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>Effetti collaterali:<\/strong><\/p>\n<ul>\n<li><strong>Comune<\/strong>Sonnolenza, vertigini, stitichezza, nausea (correlati alla codeina); incidenza del 20-30% circa negli studi clinici.<\/li>\n<li><strong>Gravi<\/strong>Depressione respiratoria (rara a basse dosi), rischio di dipendenza (la codeina \u00e8 una sostanza controllata), sovradosaggio di paracetamolo \u2192 insufficienza epatica (il metabolita tossico NAPQI sovraccarica le riserve di glutatione; rischio &gt;4 g\/giorno secondo l'MHRA).<\/li>\n<li><strong>Allergico<\/strong>: Eruzione cutanea, gonfiore.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Avvertenze e interazioni:<\/strong><\/p>\n<ul>\n<li><strong>Non combinare con<\/strong>Alcol, altri oppioidi, sedativi (aumentano il rischio di sovradosaggio \u2013 consultare le linee guida del CDC sugli oppioidi).<\/li>\n<li><strong>Evitare se<\/strong>: Gravidanza\/allattamento (la codeina passa nel latte materno), asma, malattie epatiche\/renali o precedenti di dipendenza.<\/li>\n<li><strong>Segnali di sovradosaggio<\/strong>Vomito, pupille a spillo, coma: richiedere immediatamente assistenza medica d'urgenza (naloxone per la codeina; N-acetilcisteina per il paracetamolo).<\/li>\n<li>L'Agenzia regolatoria britannica per i medicinali e i farmaci (MHRA) sconsiglia l'uso della codeina nei bambini di et\u00e0 inferiore ai 12 anni a causa del rischio di apnea (decisione del 2013 basata su dati di farmacovigilanza).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Disponibilit\u00e0:<\/strong><\/p>\n<ul>\n<li>Regno Unito: Acquisto senza ricetta in farmacia (massimo 16 compresse per confezione); prescrizione medica per quantit\u00e0 maggiori.<\/li>\n<li>USA: L'equivalente \u00e8 Tylenol #2 (di potenza simile); la codeina richiede la prescrizione medica.<\/li>\n<li>Verificate sempre le normative locali.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\">Si tratta di informazioni generali provenienti da fonti come BNF, NHS, EMA e le etichette della FDA.\u00a0<strong>not medical advice<\/strong>Consultare un medico o un farmacista per l'uso personale di Co-Codamol 15\/500mg, soprattutto in presenza di patologie preesistenti o se si assumono altri farmaci. In caso di dolore, descrivere i sintomi per ricevere consigli personalizzati.<\/p>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Co-Codamol 15\/500mg What it is: Co-Codamol 15\/500mg is a combination painkiller containing: Codeine phosphate: 15 mg (an opioid analgesic that works by binding to opioid receptors in the brain to reduce pain perception). Paracetamol (acetaminophen): 500 mg (a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system). This is &hellip; <a href=\"https:\/\/trusthillpharma.de\/it\/product\/co-codamol-15-500mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Co-Codamol 15\/500mg<\/span><\/a><\/p>","protected":false},"featured_media":7749,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[211],"class_list":["post-7736","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-co-codamol-15-500mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Co-Codamol 15\/500mg - Trusthill Pharmacy<\/title>\n<meta name=\"description\" content=\"Co-Codamol 15\/500mg is a a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trusthillpharma.de\/it\/product\/co-codamol-15-500mg\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Co-Codamol 15\/500mg\" \/>\n<meta property=\"og:description\" content=\"Co-Codamol 15\/500mg is a a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system\" \/>\n<meta property=\"og:url\" content=\"https:\/\/trusthillpharma.de\/it\/product\/co-codamol-15-500mg\/\" \/>\n<meta property=\"og:site_name\" content=\"Trusthill Pharmacy\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-14T16:02:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/trusthillpharma.de\/wp-content\/uploads\/2026\/04\/photo_5096273778597104775_x.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/trusthillpharma.de\\\/product\\\/co-codamol-15-500mg\\\/\",\"url\":\"https:\\\/\\\/trusthillpharma.de\\\/product\\\/co-codamol-15-500mg\\\/\",\"name\":\"Co-Codamol 15\\\/500mg - 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