{"id":7971,"date":"2026-04-21T13:54:28","date_gmt":"2026-04-21T13:54:28","guid":{"rendered":"https:\/\/trusthillpharma.de\/?post_type=product&#038;p=7971"},"modified":"2026-04-23T23:48:52","modified_gmt":"2026-04-23T23:48:52","slug":"neurontin-400-mg","status":"publish","type":"product","link":"https:\/\/trusthillpharma.de\/de\/product\/neurontin-400-mg\/","title":{"rendered":"Neurontin 400 mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Neurontin 400mg<\/a><\/h1>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div>\n<div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharma.de\/\">Neurontin<\/a> 400mg is the brand name for <strong>gabapentin<\/strong>, an anticonvulsant medication primarily used to treat partial seizures (in combination with other drugs) and postherpetic neuralgia (nerve pain after shingles). The 400 mg strength is a common capsule dose. It&#8217;s also frequently prescribed off-label for neuropathic pain, fibromyalgia, restless legs syndrome, anxiety, and sometimes as an adjunct for hot flashes or alcohol withdrawal.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Key Facts (Evidence-Based):<\/strong><\/p>\n<ul>\n<li><strong>Mechanism:<\/strong>\u00a0Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the CNS, reducing excitatory neurotransmitter release (e.g., glutamate). This calms overactive nerves without directly affecting GABA receptors (despite common misconceptions).<br \/>\n<em>Source: FDA label; studies in\u00a0Epilepsia\u00a0(1993) and\u00a0NEJM\u00a0(1998).<\/em><\/li>\n<li><strong>Standard Dosing (Adults):<\/strong><\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Condition<\/th>\n<th>Typical Starting Dose<\/th>\n<th>Titration<\/th>\n<th>Max Daily<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Seizures<\/td>\n<td>300 mg Day 1, 300 mg BID Day 2, 300 mg TID Day 3<\/td>\n<td>Up to 3600 mg\/day in 3 doses<\/td>\n<td>3600 mg<\/td>\n<\/tr>\n<tr>\n<td>Postherpetic Neuralgia<\/td>\n<td>300 mg Day 1, 300 mg BID Day 2, up to 300 mg TID<\/td>\n<td>Up to 1800 mg\/day<\/td>\n<td>1800 mg<\/td>\n<\/tr>\n<tr>\n<td>Off-Label (e.g., Neuropathy)<\/td>\n<td>100-300 mg at bedtime<\/td>\n<td>Increase by 100-300 mg every 1-7 days<\/td>\n<td>Varies (900-3600 mg)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><em>Neurontin 400mg\u00a0dose might be used for titration or specific regimens\u2014always per prescriber.<\/em><br \/>\n<em>Evidence: Cochrane reviews (2014, 2020) confirm efficacy for neuralgia; AAN guidelines endorse for neuropathy.<\/em><\/p>\n<ul>\n<li><strong>Pharmacokinetics:<\/strong>\n<ul>\n<li>Oral bioavailability: ~60% (decreases with higher doses).<\/li>\n<li>Half-life: 5-7 hours.<\/li>\n<li>Renal excretion: Dose-adjust for CrCl &lt;60 mL\/min (e.g., halve for CrCl 30-59).<br \/>\n<em>Source: Product monograph;\u00a0Clinical Pharmacokinetics\u00a0(1993).<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Common Side Effects (Incidence &gt;10%):<\/strong><\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Side Effect<\/th>\n<th>Frequency<\/th>\n<th>Notes<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Dizziness<\/td>\n<td>20-30%<\/td>\n<td>Dose-related; avoid driving.<\/td>\n<\/tr>\n<tr>\n<td>Somnolence<\/td>\n<td>15-25%<\/td>\n<td>Peaks early, often resolves.<\/td>\n<\/tr>\n<tr>\n<td>Ataxia\/Fatigue<\/td>\n<td>10-15%<\/td>\n<td>Elderly more susceptible.<\/td>\n<\/tr>\n<tr>\n<td>Peripheral Edema<\/td>\n<td>5-10%<\/td>\n<td>Monitor in heart failure.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><em>Data from pivotal trials (e.g.,\u00a0JAMA\u00a01998) and post-marketing surveillance.<\/em>\u00a0Serious risks: Suicidal ideation (black box warning), respiratory depression (esp. with opioids), misuse potential (Schedule V in US).<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Interactions:<\/strong><\/p>\n<ul>\n<li><strong>Major:<\/strong>\u00a0Opioids\/CNS depressants (\u2191 sedation\/respiratory risk\u2014FDA warning).<\/li>\n<li><strong>Moderate:<\/strong>\u00a0Antacids (\u2193 absorption by 20%; space 2h). Maalox reduces AUC by 20%.<\/li>\n<li><strong>No major CYP interactions<\/strong>\u00a0(not metabolized by liver).<br \/>\n<em>Evidence:\u00a0Drug Safety\u00a0reviews; Lexicomp database.<\/em><\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Warnings\/Contraindications:<\/strong><\/p>\n<ul>\n<li>Hypersensitivity to gabapentin.<\/li>\n<li>Abrupt withdrawal: Risk of seizures (taper over 1 week).<\/li>\n<li>Pregnancy: Category C; limited data, use if benefit &gt; risk (AED exposure registry).<\/li>\n<li>Overdose: Primarily sedation; treat supportively (no specific antidote). LD50 &gt;8000 mg\/kg in animals.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Evidence Summary:<\/strong><\/p>\n<ul>\n<li><strong>Efficacy:<\/strong>\u00a0Strong for neuralgia (NNT=6.5 per Cochrane); moderate for other neuropathies.<\/li>\n<li><strong>Placebo-Controlled Trials:<\/strong>\u00a012-week study (n=336) showed 400-3600 mg\/day reduced pain by \u226550% in 33% vs. 8% placebo (<em>Pain<\/em>\u00a02005).<\/li>\n<li><strong>Guidelines:<\/strong>\u00a0ADA recommends for diabetic neuropathy; NICE for trigeminal neuralgia.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Disclaimer:<\/strong>\u00a0This is general info from FDA labels, PubMed, and clinical guidelines\u2014not personalized advice.\u00a0<strong>Consult your doctor\/pharmacist for your specific case, dosing, or side effects.<\/strong>\u00a0If this is for you, share your full medical history. Need more details (e.g., generics like Neurontin equivalents)? Ask!<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex items-center justify-end gap-1 transition-opacity duration-100 opacity-0 group-hover:opacity-100 group-focus-within:opacity-100 md:absolute md:-right-10 md:-top-2\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"relative mx-auto max-w-2xl px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative mb-4 flex items-start md:-ml-12\">\n<div class=\"sm:ml-4 flex-1 space-y-2 overflow-hidden pr-1\">\n<div class=\"flex w-full items-center justify-between\">\n<div class=\"flex items-center space-x-1\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div> \n","protected":false},"excerpt":{"rendered":"<p>Neurontin 400mg Neurontin 400mg is the brand name for gabapentin, an anticonvulsant medication primarily used to treat partial seizures (in combination with other drugs) and postherpetic neuralgia (nerve pain after shingles). The 400 mg strength is a common capsule dose. It&#8217;s also frequently prescribed off-label for neuropathic pain, fibromyalgia, restless legs syndrome, anxiety, and sometimes &hellip; <a href=\"https:\/\/trusthillpharma.de\/de\/product\/neurontin-400-mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Neurontin 400 mg<\/span><\/a><\/p>","protected":false},"featured_media":7979,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[232],"class_list":["post-7971","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-neurontin-400mg","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ 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